Today’s global challenges, from climate change to health and digitalisation, are of unprecedented scientific complexity and transcend national borders, rendering isolated action ineffective. A prime example in this regard, the COVID-19 pandemic has drawn attention to the need for more science-informed public decision-making and international scientific collaboration on solutions to global crises, once again making science-policy interfaces and science diplomacy a priority for governments worldwide. At global, regional, and national levels of governance science-policy interfaces, fostering relations between scientists and policymakers to enable joint formulation of knowledge and policy solutions, are today widely established.