The Covid-19 pandemic has placed a severe strain on the health system in the world and many healthcare workers have been stretched far beyond their capacity. For most African countries, balancing a response to the pandemic with the challenges of providing universal health care has highlighted the need for resilient health systems that will address the imperatives of the UN Sustainable Development Goals and prompt novel, custom-made solutions for the continent and its people. While the collection and analysis of data across the region has enabled some of the continent’s success stories to be showcased, experts agree that the health system challenges faced by the region span over the financial, political and socio-economic spheres and that addressing them will take a multi-faceted and African approach.